Effects of Ginseng-monkshood extract injection on adverse reaction in patients undergoing Combined Spinal-epidural Anesthesia

Objective To observe the effects of Ginseng-monkshood extract injection (GEI) on hemodynamics and adverse reaction in patients undergoing combined spinal-epidural(CSE)anesthesia.Methods 42 patients aged 20-55 years,ASA physical status Ⅰ-Ⅱ,scheduled for selected hysterectomy under combined CSE anesthesia was randomly allocated to two groups(n=21):group A were injected GEI 1mL/kg dissolved in the saline 200 ml before anesthesia,and group B were injected equivalent saline instead.The following data was recorded and analyzed:blood pressure (BP) and heart rate (HR) before and after anesthesia,at CSE anesthesia and thereafter at 5 minute interval for 30 minuts,the dosge of ephedrine and atropinic,and the incidence of hypotension,bradycardia,nausea and vomiting,chills.Results Compared with base value pre-anesthesia,BP and HR were significantly decreased in both groups(P0.05).Compared with group B,BP was significantly increased from the 10th minutes of anesthesia in group A,while HR was increased only at 15 minutes after anesthesia(P0.05).Compared with group B,the dosge of ephedrine and atropinic,and the incidence of hypotension and bradycardia was significantly decreased in group A.There was no significant difference in the incidence of nausea and vomiting and chills between the two groups.Conclusion Pre-injection GEI has great significant effect in maintaining hemodynamic stability in patients undergoing CSE anesthesia,which could decrese the incidence of hypotension and bradycardia,but has no significant effects on the incidence of nausea and vomiting and chills.