HOXA10 Promotes Cell Invasion and MMP-3 Expression Via TGFβ2-Mediated Activation of the p38 MAPK Pathway in Pancreatic Cancer Cells

Xian-Ping Cui,Cheng-Kun Qin,Zhenhai Zhang,Zhongxue Su,Xin Liu,Shikang Wang,Xingsong Tian

HOXA10 Promotes Cell Invasion and MMP-3 Expression Via TGFβ2-Mediated Activation of the p38 MAPK Pathway in Pancreatic Cancer Cells

2014

Xian-Ping Cui
Cheng-Kun Qin
Zhenhai Zhang
Zhongxue Su
Xin Liu
Shikang Wang
Xingsong Tian

Background HOXA10 is closely related to tumor progression in many human cancers. However, the role of HOXA10 in pancreatic cancer remains unclear. The aim of this study was to determine the involvement of HOXA10 in pancreatic cancer cell invasion and migration.

Keywords:

Medicine
Cancer research
Endocrinology
Pancreatic cancer
Matrix metalloproteinase
Cell
Tumor progression
Oncology
Downregulation and upregulation
Blotting western
p38 mitogen-activated protein kinases
Internal medicine
Real-time polymerase chain reaction
Hepatology
cell invasion

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