A correlation study of preoperative imaging findings of central meningiomas and surgical cleavage and clinical efficacy

Objectives To investigate the correlation between preoperative imaging features of central meningiomas and surgical cleavage and to comparatively analyze the clinical efficacy of the different surgical cleavages. Methods From February 2006 to February 2014, the correlation between imaging features and surgical cleavage in 97 patients with center meningioma admitted to the Department of Neurosurgery, People's Hospital of Zhengzhou University were analyzed retrospectively. The relationship between imaging features and surgical cleavage of the tumors were tested by the univariate analysis. Kaplan-Meier survival analysis and multivariate logistic regression analysis were used to assess whether the imaging parameters predicted the surgical cleavage. Cox regression model was used to analyze the relationship between surgical cleavage or overall survival (OS) and progression free survival (PFS). Results The result of single factor analysis showed that the relationships between the peritumoral edema and the position of venous sinus, the cortical infiltration and diffusion weighted imaging (DWI) signal intensity and surgical cleavage had obvious relevance (all P 0.05). Multivariate logistic regression analysis showed that cortical infiltration was the most important independent predictor of surgical cleavage on central meningioma (P<0.01), others followed by DWI hyperintensity, parasagittal sinus, and peritumoral edema (P<0.01). The results of Kaplan-Meier analysis show that the median OS and median PFS in patients with the central grade Ⅱ meningioma. Cox regression model analysis showed that the age, WHO pathological grade, and surgical cleavage could be used as the independent predictive factors of influencing prognosis (P<0.05). Conclusions The peritumoral edema provided by preoperative imaging, the relationship with the position of venous sinus, cortical infiltration and DWI signal intensity may predict the surgical cleavage of meningioma, and the surgical cleavage is directly associated with the prognosis of patients. Key words: Meningioma; Magnetic resonance imaging; Surgical cleavage; Clinical effect