Relación de la dieta con los niveles plasmáticos de lípidos y lipoproteínas en sujetos adultos con diferentes genotipos del gen de la apolipoproteína E

Relationship between diet and serum levels of lipids and lipoproteins in adults with different apolipoprotein E genotypes. Objective. To find a possible relationship between: usual diet, lipid profile and ApoE genotypes. Materials and methods. Assessment of lipid profile, nutritional status and body fat percentage was conducted on 150 lecturers of the Pontificia Universidad Javeriana. Other variables were: age, gender, polymorphism of the ApoE gen, health status and food consumption. Results. 76 subjects were normolipidemic (NL) and 74 were hyperlipidemic (HL). Total cholesterol (TC), LDLc and triglycerid (TG) average values (mg/dl) were 164.68‐22.57; 91.82‐23.39 and 89.45‐31.13 respectively for the NL group, and 223.67‐20.25; 145.25‐19.99 and 198.74‐49.95 respectively for the HL group. Average age was 38.4‐8.4 for NL and 39.7‐8.2 for HL; gender distribution was of 31 men and 45 women in NL, and 50 men and 24 women in the HL group. ApoE genotype frequency was similar to that reported in other populations around the world. The evaluation of energy and nutrient consumption revealed an intake higher than the overall recommendation for all the nutrients, except cholesterol in HL women. Conclusion. When correlating consumption, lipid profile and genotypes, no significant differences were found, neither in lipid nor lipoprotein levels. However, a tendency was observed in the 4/3 genotype to be prone to higher cholesterol levels compared to other genotypes, especially in the HL group.