Glutathione S-transferase T1 and myeloperoxidase -463 G>A genotypes in lung cancer patients of Kumaun region.

Background: Null genetic polymorphism of Glutathione S-transferase T1 ( GSTT1 ) and -463 G>A promoter polymorphism of myeloperoxidase ( MPO ) were studied for association with lung cancer. Materials and Methods: In a case- control study 26 lung cancer patients and 33 healthy individuals from hilly Kumaun region of northern India were investigated. DNA was extracted from peripheral blood. GSTT1 null polymorphism was detected by duplex PCR, and MPO polymorphism was detected by performing PCR-RFLP. Results: An increased but statistically non- significant risk for lung cancer was found for GSTT1 null genotype. No association for MPO -463G>A genotype was evident. Conclusion: Further study with large sample size may reveal such association in this population.