Successful treatment by intralesional steroid injection in management of central giant cell granuloma of the jaw—Report of two cases

Abstract Intralesional steroid injections were administered in two patients with central giant cell granuloma of the jaw (CGCG). In these patients, intralesional corticosteroid injections resulted in disappearance of the lesions and callus formation at the sites of bone resorption on radiographs during follow-up. Surgical curettage or excision and radiation therapy have been reported as treatments for CGCG, in addition to intralesional steroid injection. However, CGCG occurs predominantly in young adults. Considering the tissue defects caused by surgical treatments and side effects of drugs, intralesional steroid injection appears to be the most minimally invasive procedure and to yield favorable results. In treatment of CGCG, intralesional corticosteroid injection, a minimally invasive procedure, could be considered the first choice for treatment of CGCG, while surgery should be performed for recurrence.