Platelet volume indices in acute coronary syndrome - a case control study

Background: Acute coronary syndrome (ACS) is a set of signs and symptoms due to rupture of a plaque which are a consequence of platelet- rich coronary thrombus formation. The aim of study was to compare the platelet volume indices (PVI) in acute coronary syndrome with healthy controls. Methods: The study was carried out on 100 cases diagnosed with acute coronary syndrome and 50 controls from June 2012 to September 2014. Results:  All  platelet volume indices i.e. mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (PLCR) were significantly raised in patients with acute myocardial infarction (AMI) and unstable angina (UA), (MPV 9.2 fl, PDW 11.3 fl, PLCR 19.3 fl,) compared to those with control group (MPV 8.6 fl, PDW 10.2 fl, PLCR 15.8 fl). Conclusions:  PVI are simple investigations that can be used for predicting impending acute cardiovascular events.