Study on chemical constituents of Toddalia asiatica

OBJECTIVE: To investigate the chemical constituents of Toddalia asiatica. METHODS: The compounds were isolated and pu- rified by column chromatography and their structures were identified on the basis of physicochemical properties and spectral data analysis. RESULTS: Sixteen compounds were isolated and identified as zanthocadinanine A(1), pimpinellin(2), isopimpinellin(3), phellopterin (4), armottianamide(5), chelerythrine(6), nitidine(7), chlorogenic acid (8), toddalolactone (9), protopine(10), skimmianine(11), dictamine(12), toddalenone(13), beta-sitosterol(14), bergapten(15) and 8-hydroxy-6-methoxycoumarin(16). CONCLUSION: Compound 1 and 16 are isolated from Toddalia genus for the first time.