A NOVEL TECHNICAL DEVELOPMENT AND EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF SIMVASTATIN
2014
The research article includes self-emulsifying drug delivery systems (SEDDS) are usually used to improve the bioavailability of drugs. Simvastatin is poorly water soluble drug. Aim of present study was to develop novel dosage form of self-emulsifying drug delivery systems (SEDDS) of Simvastatin. Article deals that before the formulation of SEDDS, solubility study was performed on different exicipients, and exicipients are selected on the basis of solubility in simvastatin. From the solubility study, better solubility was seen in oleic acid (oil), tween80 (surfactant), PEG 200 (cosurfactant) and ethanol (co-solvent). No drug exicipients interaction was seen. Particle size was 100 to 300 nm. Drug release up to 96.75 % in 3.5 hrs and showed excellent stability. SEDDS Simvastatin oral formulations were prepared that provides excellent drug solubilization, drug stability in water and improved in vitro release of simvastatin.
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