Simultaneous HPLC Estimation Of Acetaminophen, Chlopheniramine Maleate, Dextromethorphan Hydrobromide And Pseudoephedrine Hydrochloride In Tablets

A simple and precise reversed phase HPLC method has been developed for the simultaneous estimation of acetaminophen, chlorpheniramine maleate, dextromethorphan hydrobromide and pseudoephedrine hydrochloride in tablet on a I¼ Bondpak phenyl bonded (30 cm x 3.9 mm) column using methanol:buffer (50:42.5, adjusted to pH 3.6 using orthophosphoric acid) as a mobile phase at a flow rate of 1.5 ml/min and detection at 214 nm. The retention times of acetaminophen, pseudoephedrine hydrochloride, chlorpheniramine maleate and dextromethorphan hydrobromide have been found to be 2.39, 4.01, 10.15 and 13.72 min, respectively and the recoveries from tablets were between 99-101%. Validation of the proposed method also been done. The method can be used for estimation of combination of these drugs in tablet.