116 Effect of nebulised antibiotics on Aspergillus colonisation and complications

Nebulised antibiotics are associated with increased Aspergillus colonisation. It is not known whether this effect leads to increased Aspergillus antibodies or more frequent use of anti-fungal medication. Recent in-vitro data also suggests that colomycin may have fungicidal properties. We reviewed 129 adult patients classified as chronically colonised with Pseudomonas. Patients were receiving either long-term nebulised colomycin, nebulised tobramycin, or no antibiotic (Table 1). Patients not receiving nebulised antibiotics had lower Aspergillus positivity in sputum (p = 0.003) and lower specific Aspergillus IgE levels (p = 0.001). There was a trend to lower total IgE and use of anti-fungal medication. No significant differences were seen between the colomycin and tobramycin groups aside from the colomycin group received less anti-fungal medication (p = 0.03).