Different chromosomal alterations correlate with gene expression in African American (AA) versus Caucasian American (CA) prostate cancer (PC) patients

5000 Background: We used a genome wide approach to identify chromosomal and gene expression alterations that might explain the aggressive clinical behavior of PC in AA compared with CA patients. Methods: We frequency matched 20 AA with 20 CA patients for potential confounding factors (PSA, age, Gleason grade, pathologic stage). We utilized array-CGH (Spectral Genomics), to identify noteworthy genomic regions with significantly different chromosomal alterations between the 2 groups. RNA samples were available for 19 AA and 14 CA patients. Gene expressions were examined using Affymetrix HG-U133 Plus 2.0 arrays. Correlations were examined between the noteworthy altered chromosomal regions and gene expression. Results: Regions of chromosomal gain or loss in each sample were determined using the circular binary segmentation approach coupled with an outlier detection method to identify singleton markers exhibiting alterations. We identified 28 chromosomal regions that were significantly different between the 2 ...