Pharmacological correction of the ulcerogenic action of NSAIDs in rats

Abstract Experimental preclinical investigations on a group of 90 white outbred male rats showed that preliminary preventive introduction of procaine (novocaine, 1.07 mg/kg) or taurine (7.14 mg/kg) during 7 days before the administration of ketorolak trometamine significantly reduced the number of erosive-ulcerous lesions (by more than 87%, p < 0.001) and decreased the extent of pathological changes in the morphological structure of stomach mucus membrane.