THE PAUSON-KHAND REACTION IN SYNTHESIS OF BICYCLIC RIGID α-AMINO ACIDS

The combination of intramolecular Pauson-Khand methodology for Co2(CO)8 mediated cyclization, and the Schollkopf chiral auxiliary for stereoselective preparation of appropriate 1,6-heptenynes constitutes a powerful method for the preparation of rigidified bicyclic α-amino acids.