Accumulation, excretion and metabolism of 2,4,6-trichlorophenyl-4′-nitrophenyl ether by carp

Abstract 1. 1. The bioconcentration factors (BCF) of 2,4,6-trichlorophenyl-4′-nitrophenyl ether (CNP) in carp were 334 ± 13 (mean ± SD, n = 3) for muscle, 542 for liver, 862 for kidney and 547 for gallbladder after 14 days exposure. 2. 2. The excretion rate constants ( k ) of CNP by carp were 0.12 day −1 for muscle, 0.11 day −1 for liver, 0.28 day −1 for kidney and 0.14 day −1 for gallbladder assuming their processes to be first-order kinetics. 3. 3. 2,4,6-Trichlorophenyl-4′-aminophenyl ether (CNP-amino), 2,4,6-trichlorophenyl-4′-acetamide phenyl ether (CNP-acetamide) and 2,4,6-trichlorophenyl-4′-formamide phenyl ether (CNP-formamide) were detected as metabolites of CNP in muscle and viscera of carp.