Successful treatment of left sided native valve MRSA endocarditis in immunocompromised host treated with daptomycin and surgery: a case report

Infections of the left side of the heart, involving the aortic or mitral valves, have greater therapeutic failure rates than those of the right side. The emergence of antimicrobial resistance amongst gram-positive pathogens, particularly Methicillin- Resistant S Aureus (MRSA) has made treatment more difficult. Daptomycin is a newer option for treatment of bacteraemia and endocarditis due to MRSA. Infective endocarditis is an important clinical mimic of vasculitis. We report here a case of left sided native valve endocarditis due to MRSA in an immunosuppressed host successfully treated with surgery and daptomycin.