Experimental studies on xenotransplantation of pretreated neonatal pig islets

In order to look for a better islet pretreatment technique to decrease the immunogenicity,the studies on xenotransplantation of neonatal pig islets pretreated by 24℃ culture,Laser-irradiation and cryopreservation were conducted.Forty-nine rats(41.18%)were proved to be effective.But only 1(11.10%)was effective in nine control rats.The survival time of the pretreated group were 11.94±5.77days,and that of control group 9 days.The results indicated that the immunogenicity of pretreated neonatal pig islets were reduced markedly,and the effecacy of the transplantation was significantly increased compared to that of control group. Key words: Swine; Islands of langerhans; Handling; Transplantation,heterologous