Effects of Combined Chelation Treatment with Pyridoxal Isonicotinoyl Hydrazone (PIH) Analogs and Deferoxamine in Hypertransfused Rats and in Iron-Loaded Rat Heart Cells Running Head: Combined PIH analog and DFO Chelation Treatment Heading: Red Cells

Gabriela Link , Prem Ponka, Abraham M Konijn, William Breuer, Z Ioav Cabantchik and Chaim Hershko . Department of Human Nutrition and Metabolism, Hebrew University Hadassah Medical School, Department of Biological Chemistry, Institute of Life Sciences, and Department of Medicine, Shaare Zedek Medical Center, Hebrew University of Jerusalem , Jerusalem, Israel and Lady Davis Institute for Medical Research, Montreal, Quebec, Canada