P-0218 Relevance of Vitamin D (25OHD) Levels in Early Stage Colorectal Cancers

ABSTRACT Introduction Vitamin D deficiency is associated with increased colorectal cancer risk and decreased colorectal cancer survival. The purpose of this study was to determine the effect of colorectal cancer adjuvant treatment on the vitamin D status as measured by serum hydroxyvitamin D (25OHD) in colorectal cancer patients. Methods 102 patients at the GHSU Cancer center with early stage colorectal cancer were selected between 2009 -2011. A retrospective analysis of baseline vitamin D in patients with early stage (Stage I, II, III) was made to determine if vitamin D level predicts survival. All patients were being treated in the curative setting, patients with metastatic cancer, those who had received neoadjuvant treatment were excluded. Only patients who had a baseline vitamin D level drawn at baseline were selected. Vitamin D sufficiency was defined as serum level of 30ng/ml or greater, insufficiency as 20 to 29ng/ml and deficiency as less than 20ng/ml. Information regarding type of chemotherapy received, performance status, body mass index, and demographic data were obtained from patients charts. Results Mean age of the patients was 76.4 years.45 % were stage I, 35% comprised Stage II and 25% were Stage III.25OHD Level was insufficient in 85% and deficient in 10% and sufficient in only 5% of the patients. In the patients who received chemotherapy (45%), those with sufficient vitamin D levels had a statistically longer survival than those with deficient levels (p Conclusion Majority of patients with newly diagnosed early stage colorectal cancer are vitamin D deficient at the time of diagnosis. Those with sufficient and higher levels of vitamin D are associated with better survival. Whether aggressive vitamin D repletion would improve the outcome in vitamin D deficient colorectal cancer patients remains unknown. Clinical trials addressing this question are warranted. Further research is warranted to explore the role of vitamin D in survival of colorectal cancer patients.