INFLUENCE OF PHYSICAL ACTIVITY PRACTICE IN THE HAND GRIP FORCE-TIME CURVE IN STATINS USERS

Introduction:Studies on the effect of statins on muscle strength are contradictory, with maeger evidence of the influence in physical activity on the pattern of muscle contraction of its users. Objectives:The objective of the study was to verify the effect of physical activity practice on the force-time curve of handgrip.Method: For this purpose, 40 women (50-75 years) on statins (≥4 months), divided into Statin Sedentary Group (SSG), n = 13), Statin Exercise Group ([SExG], n = 13) and Exercise Group [ExG], n = 14), the biochemical profile, body composition and handgrip strength-time curve were evaluated. Results:The results indicated a significant difference in time to achieve peak force (TFP) between the groups with and without statins (SExG = 2.8 ± 1.0 and GES = 2.5 ± 1.1 vs GEx = 1.5 ± 0, 7), and the percentage of force loss (% FL) between the groups exercised (SExG = 7.8 ± 5.8 vs. ExG = 24.4 ± 20.3). There was a significant significant correlation between exposure to statins and PFT values (r = 0.549), as well as% PF (r = 0.422); There was a moderate and significant inverse correlation between% PF versus PFT (r = -0.568), and between% PF versus final force (r = -0.603). Conclusion:The results suggest that statins may interfere with the values of the hand grip Force-time curve, and physical activity may contribute to attenuate the side effects of the muscle contraction pattern caused by regular use of this medication.