Therapeutic Application of Perinatal Mesenchymal Stem Cells in Nervous System Diseases

The nervous system diseases or disorders are caused by the malfunction and abnormalities in the nerves, spinal cord, or brain, resulting in paralysis, seizures, confusion, or distorted perception. The currently available regimens to restore the impaired or lost neurologic functions are limited and not effective. Thus it is urgent to find novel strategies to address the unmet medical need. Stem cell therapy provides a promising strategy in the treatment of nervous system diseases. Perinatal mesenchymal stem cells (MSC) are ideal cell candidates for the cell-based therapy for nervous system diseases, and recent advances have showed that perinatal MSC transplantation is safe and effective in both preclinical and clinical studies in several nervous system diseases including stroke, spinal cord injury, Parkinson’s disease, and Alzheimer’s disease.