Drug-Induced Liver Injury by Dietary Supplements in Japan

Recently, cases of drug-induced liver injury (DILI) by dietary supplements including socalled health foods and herbal medicines have increased in Japan. Much attention has been paid to DILI by dietary supplements since the reports of many cases of severe liver injury by Chinese dietary supplements in July 2002. The increased use of dietary supplements due to a health boom derived from the increase in patients with lifestylerelated illness and doctors’ knowledge of DILI