Process for the preparation of the mesylate salt of il-12 inhibitor compounds

Disclosed is a production inhibitor of IL-12, IL-23 and / or IL-27, nitrogen - provides a method for the preparation of heteroaryl systems mesylate salt. A methanesulfonate of the formula (I), or a pharmaceutically acceptable solvate, clathrate, inclusion hydrate, a method for the preparation of the crystalline polymorph or prodrug thereof. The method of the present invention, generate less decomposition products than prior art methods. Further, since no reference to alcohol as a solvent, alkyl esters of methanesulfonic acid is not formed. That is, the method of the present invention increases the purity of the IL-12 inhibitor compounds, for methanesulfonic acid alkyl ester impurity content in prepared methanesulfonic acid salt is extremely small, the cost and time reduction required for their preparation to. .BACKGROUND