Growth cartilage expression of growth hormone/insulin-like growth factor I axis in spontaneous and growth hormone induced catch-up growth

article i nfo Introduction: Catch-up growth following the cessation of a growth inhibiting cause occurs in humans and an- imals. Although its underlying regulatory mechanisms are not well understood, current hypothesis confer an increasing importance to local factors intrinsic to the long bones' growth plate (GP). Aim: The present study was designed to analyze the growth-hormone (GH)-insulin-like growth factor I (IGF- I) axis in the epiphyseal cartilage of young rats exhibiting catch-up growth as well as to evaluate the effect of