Delivery of cell membrane impermeable peptides into living cells by using head-to-tail cyclized mitochondria-penetrating peptides
2019
A series of cyclic Arg-rich mitochondrial penetrating peptides were prepared with variation at macrocycle size and the chirality of Arg residues. A cyclic heptapeptide was demonstrated as an efficient mitochondria-specific delivery vector for delivering membrane impermeable peptides.
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