Study on the relationship between FcγRIII gene polymorphisms on lymphocytes surface and immune related diseases

LgG plays all important role in the humoral immune mediated by antibody-dependent celhhr cy-totoxicity(ADCC).It combines specific receptors on effector cells to mediate different immune responses.FcγR m(CDl6),which is on the surface of human leukocytes,which bind to antibodies.It has two gene polymorphisms:FcγRⅢA and FcγR Ⅲ B.Genetic polymorphisms of each one affects their binding ability to the subtype of lsg,thus influences humoral immune by inducing different immune responses.CDl6 gene polymorphisms has a close relationship with the occurrence and development of immune related diseases-This paper is to summarize this relationship. Key words: CD16; FcγRⅢ; Immune; Gene polymorphism