EFFECT OF CIRCULATING 25-HYDROXY VITAMIN D STATUS IN SHORT STATURE PATIENTS UNDERGOING CONCURRENT HORMONE THERAPY, AN INSTITUTIONAL STUDY

Accurate anthropometric measurements and critical analysis of growth data allow the clinician to promptly recognize children with short stature. Vitamin D deficiency (VDD) is widespread, yet it is the most underdiagnosed and undertreated nutritional deficiency in the world. The aim of this study was to determine the Effect of circulating 25-hydroxyvitamin D status in short stature patients undergoing Concurrent hormone therapy among children referred to the department of pediatric and endocrinology, Institute of medical Science, Banaras Hindu University. Methods: Blood was collected form the endocrinology OPD Sir Sunderlal Hospital IMS BHU complete blood count, calcium, phosphorus, alkaline phosphatase, 25 (OH) Vitamin D levels (by automated chemiluminescent immunoassay) on subjects suffering from Short Stature to record the details of their lifestyle, habits and familial history. All subjects were of Indian ethnicity from Eastern Uttar Pradesh and Bihar, the two states of northern Indian population.  Patients were characterized in terms of their socio-demographic and clinically diagnosed characteristics, Evaluation included: detailed medical history, physical examination, laboratory tests, bone age and chromosomal analysis. Results:  A total of 70 patients with short stature were involved in this study. The patient age for the study was taken 18 years (range 4 to 18 years) and 38 (54%) were male. The chosen patient to study their height and weight were below the 2 Standard deviation or third percentile there chronologic age in 57 (81%) patients. The leading cause of short stature in our population was Growth Hormone (GH) deficiency seen in 48 out of 70 (69%) patients. Conclusions: Several previous studies suggested that Vitamin D deficiency constitutes one of the major causes of short stature among fine-nurtured short stature children in India. If Primary recognition of short stature cannot help only average height attend but also improve their quality of life and social standing. All-purpose if diagnostic was done early need to be cognizant of and refer patients promptly to an endocrinologist for timely treatment.