Metabolism of pseudouridine in rats with acute carbon tetrachloride intoxication

: After acute intoxication with CCl4 excretion of pseudouridine with urine was increased. At the some time, pseudouridine content was decreased in soluble RNA from liver tissue and unaltered in ribosomal RNA. The rate of pseudouridine turnover was studied by means of elimination of its total and specific radioactivity in urine, sRNA and rRNA. An increase in the pseudouridine excretion occurred due to acceleration in rRNA turnover and to an increase in the sRNa degradation, which was synthesized before CCL4 administration, but a decrease of pseudouridine content in sRNA was caused by inhibition of its synthesis.