Absence of Effect of Swallowed Saliva on Coagulation of Blood

It has been shown1, 2 that saliva added to shed blood has a remarkable accelerating action both on normal and haemophilic bloods. It was thought desirable to see if saliva, when swallowed, had any effect on the coagulating time of blood or contributed in any way to its coagulability. Mills3, 4 has shown that the ingestion of a meal rich in protein has an accelerating effect on the coagulation of blood but the ingestion of fats or carbohydrates has little effect.The results of this work may be briefly stated. It is easy to confirm Mills observations. Thus a meal of 600 gm. of meat caused a reduction of clotting time from 3 1/4 minutes to 1 minute 54 seconds two hours after the meal. No, or at most a few seconds, reduction in clotting time resulted from carbohydrate or fat meals and this is true also for the ingestion of large amounts of saliva. Paraffin or gum was chewed for 15 to 30 minutes and the saliva swallowed as formed. Samples of blood were taken every 15 minutes and in no case was any material dif...