Effects of superoxide dismutase on some biological characteristics of lung cancer cellsIn vivo andIn vitro

The present study observed the effects of superoxide dismutase (SOD) and its inhibitor, diethyldithiocarbamate (DDC), on the metastasis of Lewis Lung cancer and some biological characteristics of A549 lung cancer cell line. It was found that SOD and DDC inhibited significantly the metastasis of Lewis lung cancer in C57 BL mice, which the effect of DDC was more significant than that of SOD, and decreased the proliferation of A549 lung cancer cell and its transplantation rate in nude mice.