A comprehensive review on methemoglobinemia

Methemoglobinemia is a blood condition in which the production of methemoglobin (MetHb) is irregular and thus unable to adequately release oxygen to body tissues. This is largely because MetHb is the altered hemoglobin (Hb) state in which heme's ferrous iron has been oxidized to the ferric state. This review paper explores in depth the various forms of methemoglobinemia and the biochemical pathways and mechanisms of their causes. If they have cyanosis, patients with high MetHb in the blood can look blue, but the methylene blue solution will heal them. However, for strategic care, proper management should be identified. This analysis would be helpful in learning the basics of methemoglobinemia and its current treatment with recommendations for health care professionals, pharmacists, biochemists, and researchers. This study will allow readers to understand methemoglobinemia and will be a ready guide for it.