Linkers cyclic P1 factor XIa as inhibitors

A compound of Formula (Ia): ** ** Formula or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate thereof, wherein: G1 is selected from the group consisting of a 6-membered aryl and 5- to 6-membered, wherein they said aryl and heteroaryl are substituted with 1-5 R8; ring A is selected from the group consisting of a 6-membered aryl and a 5- to 6-membered, wherein said aryl and heterocyclic are substituted with 1-3 R13; X is selected from the group consisting of C4-8 alkylene and C4-8 alkenylene, wherein said alkylene and alkenylene are substituted by R1, R2 and R6; alternatively, one or more of the carbon atoms of said alkylene and alkenylene may be replaced by O, C> = O, S (O) p, NH and N (C1-4 alkyl); X2 is selected from the group consisting of CHR11, C> = O, O, NH and N (C1-4 alkyl); X3 is CR12 or N; X3 is CR12 provided that when X2 is O, NH or N (C1-4 alkyl); R1 and R2 are independently selected from the group consisting of H, halogen, C1-6 alkyl, OH, NH2, -CH2NH2, C1-4 haloalkyl, -OCH 2 F, -OCHF 2, -OCF 3, NH (C1-4 alkyl) alkyl, N (C1-4alkyl) 2, C1-4alkoxy, -CH2OH and -CH 2 O (C1-4 alkyl); alternatively, R1 and R2 are taken together with the carbon atoms to which they are attached to form a carbocycle; R3 is selected from the group consisting of H, haloalkyl, -C (> = O) OH, -C (> = O) O-C1-4 alkyl and -C (> = O) NR9R10; R4 is selected from the group consisting of H and C1-6 alkyl; alternatively, R3 and R4 are, together,> = O; R5 is independently selected from the group consisting of H, halogeno, C1-4 alkyl, OH, CN, NR9R10, NO2, C1-4 alkoxy, -C (> = O) OH, -C (> = O) O (alkyl C1-4), -C (> = O) NH2, C (> = O) NR9 (C1-4 alkyl), -C (> = O) NR9-C 1-4 alkylene or (C1-4 alkyl), -NR9C (> = O) C1-4 alkyl, -NR9C (> = O) OC 1-4 alkyl, -NR 9 C (> = O) C 1-4 alkylene-O (C1-4 alkyl), - NR 9 C (> = O ) Oalquilen C1-4-O (C1-4 alkyl), -NR9C (> = O) NH (C1-4 alkyl), R15, -C (> = O) OR15, -C (> = O) NR9R15, - NR9R15, - NR 9 C (> = O) R15 and -NR9C (> = O) OR15; R5a is selected from the group consisting of H, halogen and methyl; R6 is selected from the group consisting of H, C1-6 alkyl and OH; R7 is selected from the group consisting of H, 2H, F,> = O, OH and C1-4alkyl; R8 is selected from the group consisting of H, halogen, OH, CN, C1-6alkyl, haloalkyl, alkoxy, haloalkoxy, and -C (> = O) C1-3alkyl; R9 is selected from the group consisting of H and C1-6 alkyl; R10 is selected from the group consisting of H and C1-6 alkyl; alternatively, R9 and R10 are taken together with the nitrogen atom to which they are attached to form a 4- to 7-membered substituted with R14; R11 is selected from the group consisting of H and C1-6 alkyl; R12 is selected from the group consisting of H, 2H and C1-6 alkyl; R13 is selected from the group consisting of H, OH, halogen, CN, C1-6 alkyl, alkoxy, haloalkyl, haloalkoxy and C3-6 cycloalkyl; R14 is selected from the group consisting of H, OH, halogen and C1-6alkyl; R15 is selected from the group consisting of: - (CH2) n-C3-10 carbocycle and - (CH2) n-4-10 membered heterocycle, wherein the carbocycle and heterocyclic are optionally substituted with C1-6 alkyl, cycloalkyl C3-6, - (CH2) n- C (> = O) OC 1-4 alkyl, - (CH2) n-O-C1-4 alkyl and> = O; n, in each case, is selected from 0, 1, 2, 3 and 4; p, at each occurrence, is selected from 0, 1 and 2.