THU0225 Hypogonadotropic Hypogonadism in Systemic Arthritis- An Interesting Case Series from A Tertiary Care Centre

Background The musculoskeletal, cardiac, pulmonary, hepatic, reticuloendothelial, hematological, neurological manifestations of systemic arthritis are very well known. Hormonal abnormalities of systemic arthritis have not been reported thus far Objectives To study hormone profile in systemic arthritis and identify abnormalities Methods We present a case series of abnormal hormone profile in 5 consecutive cases of Systemic arthritis admitted and evaluated at Institute Of Rheumatology, Madras Medical College during Februrary 2015. All patients had high systemic disease activity – elevated ESR, CRP, ferritin, fibrinogen, thrombocytosis. Fasting serum hormone profile was done by chemiluminescence method – Adrenocorticotropin releasing hormone (ACTH), Thyroid stimulating hormone (TSH), Follicle stimulating hormone (FSH), Luteinizing hormone (LH), Prolactin, Testosterone, Insulin like growth factor-1 (IGF-1), Growth hormone (GH) were estimated. Results All 5 patients had low serum FSH,LH,GH,Testosterone levels. All 5 patients had normal ACTH,TSH,prolactin levels. * indicates LOW VALUES Conclusions –Hypogonadotrophic secondary hypogonadism was observed in 5 consecutive patients with systemic arthritis with high disease activity. –We are presenting this case series as no studies have so far been reported on hormone profile of patients with systemic arthtritis to the best of our knowledge. –Further studies with more number of cases are needed to find out whether the endocrine dysfunction is disease related or drug induced. References Harel L, Prais D, Uziel Y, Mukamel M, Hashkes P, Harel G, Amir J, Monselise Y, Press J.Increased prevalence of antithyroid antibodies and subclinical hypothyroidism in children with juvenile idiopathic arthritis. J Rheumatol. 2006 Jan;33(1):164–6 Bechtold S, Ripperger P, Hafner R, Said E, Schwarz HP. Growth hormone improves height in patients with juvenile idiopathic arthritis: 4-year data of a controlled study.J Pediatr. 2003 Oct;143(4):512–9. Khalkhali-Ellis Z, Moore TL, Hendrix MJ. Reduced levels of testosterone and dehydroepiandrosterone sulphate in the serum and synovial fluid of juvenile rheumatoid arthritis patients correlates with disease severity. Clin Exp Rheumatol. 1998 Nov-Dec;16(6):753–6. Disclosure of Interest None declared