High-efficiency translational bypassing of non-coding nucleotides specified by mRNA structure and nascent peptide.

Translational bypassing occurs when the ribosome skips nucleotides downstream of a take-off codon and re-initiates protein synthesis at a location further down on the mRNA. Here, Samatova et al. show that translational bypassing of bacteriophage T4 gene60 mRNA is specified both by the mRNA sequence and the nascent peptide.