Use of membranes based on collagen as tissue substitutes

: Collagen, as biocompatible and bioactive non-specific polymer, occupies prominent position in the field of tissue engineering. The advanced biomaterials prefer collagen as a matrix for biodegradable implants as are biosynthetic skin substitutes, tendon and ligament substitutes, but also cartilage. Many studies notice the application of chemically modified collagen membranes for hernia and anastomoses reparations, vascular prosthetic materials, or for collagen tubes used in regeneration of peripheral nerves. Besides of defining main problems of tissue engineering, the paper analyses the developmental tendency of these biomaterials in the world, and compares it with the situation in Slovak Republic.