Usage of warfarin as a reference drugin experiments on rats

The possibility of using indirect anticoagulant warfarin as a reference drug in sсreening researches on rats was considered in the article. The dose of warfarin leading to true increase of prothrombine time without any internal gemorrhagias in animals has been defined. The optimal terms of administration for warfarin were defined. The dose-dependent regularity of warfarin effect from its duration of administration to rats was revealed.