Chemometric approach to evaluate catalytic activity of [CTAB/ 18-Crown-6]: A binary catalytic system for one pot green synthesis of 4-benzylidene-3-methylisoxazol-5(4H)-one derivatives at room temperature

A highly efficient binary catalytic system [CTAB/ 18-Crown-6] has been developed for one pot three component green synthesis of 4-benzylidene-3-methylisoxazol-5(4H)-one derivatives by reaction of aromatic aldehydes, ethyl acetoacetate and hydroxylamine hydrochloride. Catalytic productivity of [CTAB/ 18-Crown-6] has been studied using different ratio combination of cetyltrimethylammonium bromide (CTAB) and 18-Crown-6 in varying water: ethanol ratio. Percent yield of isoxazol-5(4H)-ones obtained by different [CTAB/ 18-Crown-6] ratio in variable water: ethanol solution were analyzed by descriptive statistical analysis and variable correlation analysis to evaluate the catalytic efficacy of binary [CTAB/ 18-Crown-6] system.