Abstract 15559: Comparison of Cardiac Output Assessment With Two Different Minimally-invasive Pulse Contour Analysis-monitoring Devices and Echocardiography During Mild Therapeutic Hypothermia and Normothermia

Background: Post-cardiac arrest myocardial dysfunction and hemodynamic instability characterize survivors of out-of-hospital cardiac arrest (OHCA). There is a need for optimal hemodynamic monitoring including cardiac output, during both mild therapeutic hypothermia (MTH) and the following normothermic period. Clinical practice using less invasive techniques based on arterial waveform analyses have gained increased interest. Hypothesis: Minimally invasive hemodynamic monitoring devices with thermodilution calibration provide more precise cardiac output (CO) measurements during MTH than measurements without calibration. Methods: Comatose OHCA survivors receiving MTH underwent hemodynamic monitoring with arterial pulse contour analyses with transpulmonary thermodilution calibration (PiCCO2 plus system, Pulsion Medical systems, Munich, Germany) and without calibration (FloTrac pressure sensor, Vigileo monitor, Edwards Lifescience, Irvine, USA) every eight hours during 24 hours of MTH and the following 24 hour...