[Relationship between circulating vascular cell adhesion molecule-1 and vascular complications in type 2 diabetes mellitus].

Objective To investigate the relationship between soluble vascular cell adhesion molecule 1(sVCAM 1) and type 2 diabetes complicated with vascular diseases. Methods In 61 cases of type 2 diabetes with macrovascular or microvascular complications and 36 cases of healthy control , sVCAM 1 levels were measured in duplicate by enzyme linked immunosorbent assay using the soluble VCAM 1 Kit (R D Systems Ltd, Ablingdon, Oxfordshire,UK). Results sVCAM 1 levels in type 2 diabetes [(973 25±73 38) μg/L] were higher than these of healthy controls [(230 45±12 47) μg/L], P 0 001 sVCAM 1 levels of type 2 diabetes with hypertension [(1263 99±87 00)μg/L] were higher than those of type 2 diabetes with microvascular complications[(726 57±95 40) μg/L], P 0 001 Conclusion There was a significant correlation between sVCAM 1 concentration and vascular complications of type 2 diabetes