Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists

We describe a series of 1,2,4-oxadiazoles, which are potent antagonists of the integrin α v β 3 and, in addition, show selectivity relative to the other β 3 integrin α IIb β 3 . In whole cells, the majority of these analogs also demonstrated modest selectivity against other α v integrins such as α v β 1 and α v β 6 .