[Zinc modulation of GABA receptors expressed in Xenopus oocytes injected with carp brain poly(A)+ RNA].

Two types of GABA receptors, GABAA receptors (approximately 85 % ) and GABAClike receptors (approximately 15 % ), were expressed in Xenopus oocytes after injection of Poly(A) + RNA With cap (Carassius carassius ) brain. Using voltage-clamp technique and pharmacological methods, the effects of zinc on the two receptors were studied. It was found that zinc modulation of both GABAA and GABAc-like receptors by zinc was inhibitory and reversible with the former being stronger than the latter as indicated by a value of IC5o of 48 .4 ±10.1μmol/L against 255. 6±21. 5 μmol/L.