C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma

Jamileh A. Nabizadeh,Helga D. Manthey,Nadya Panagides,Frederik J. Steyn,John D. Lee,Xaria X. Li,Fazrena Nadia Md Akhir,Weiyu Chen,Glen M. Boyle,Stephen M. Taylor,Trent M. Woodruff,Barbara E. Rolfe

C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma

2019

Jamileh A. Nabizadeh
Helga D. Manthey
Nadya Panagides
Frederik J. Steyn
John D. Lee
Xaria X. Li
Fazrena Nadia Md Akhir
Weiyu Chen
Glen M. Boyle
Stephen M. Taylor
Trent M. Woodruff
Barbara E. Rolfe

The canonical complement component 5a (C5a) receptor (C5aR) 1 has well-described roles in tumorigenesis but the contribution of the second receptor, C5aR2, is unclear. The present study demonstrate...

Keywords:

Endocrinology
Internal medicine
Carcinogenesis
Diabetes mellitus
Complement component 5a
Cancer research
Biology
Receptor
Melanoma

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