Preclinical Validation of PLAG1 Fluorescence In Situ Hybridization Assay as an Ancillary Tool in the Differential Diagnosis of Lipomatous Neoplasms

Distinguishing lipoblastoma from entities with overlapping histopathologic features such as myxoid liposarcoma, conventional lipoma, hibernoma, fibromatosis, and fat necrosis is necessary for optimal patient care. Of potential usefulness, pleomorphic adenoma gene 1 (PLAG1) alterations are characteristic of lipoblastoma and absent in the aforementioned entities. PLAG1 is a zinc-finger transcription factor expressed during late stages of …