Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria : a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

Prabin Dahal,Julie A. Simpson,Salim Abdulla,Jane Achan,Ishag Adam,Aarti Agarwal,Richard Allan,Anupkumar R. Anvikar,Emmanuel Arinaitwe,Elizabeth A. Ashley,Ghulam Rahim Awab,Quique Bassat,Anders Björkman,François Bompart,Steffen Borrmann,Teun Bousema,Ingrid van der Broek,Hasifa Bukirwa,Verena I. Carrara,Marco Corsi,Michel Cot,Umberto D'Alessandro,Timothy M. E. Davis,Marit de Wit,Philippe Deloron,Meghna Desai,Pedro Rafael Dimbu,Djibrine Djalle,Abdoulaye A. Djimde,Grant Dorsey,Ogobara K. Doumbo,Chris Drakeley,Stephan Duparc,Michael D. Edstein,Emmanuelle Espié,Abul Faiz,Catherine O. Falade,Caterina I. Fanello,Jean-François Faucher,Babacar Faye,Filomeno Fortes,Nahla B Gadalla,Oumar Gaye,J. Pedro Gil,Brian Greenwood,Anastasia Grivoyannis,Kamal Hamed,Tran Tinh Hien,David Hughes,Georgina S. Humphreys,Jimee Hwang,Maman Laminou Ibrahim,Bart Janssens,Vincent Jullien,Elizabeth Juma,Erasmus Kamugisha,Corine Karema,Harin Karunajeewa,Jean René Kiechel,Fred Kironde,Poul-Erik Kofoed,Peter G. Kremsner,Valerie Lameyre,Sue J. Lee,Kevin Marsh,Andreas Mårtensson,Mayfong Mayxay,H. Menan,Petra F. Mens,Theonest K. Mutabingwa,Jean Louis Ndiaye,Billy Ngasala,Harald Noedl,François Nosten,André Touré Offianan,Mary C. Oguike,Bernhards Ogutu,Piero Olliaro,Jean-Bosco Ouédraogo,Patrice Piola,Christopher V. Plowe,Mateusz M. Plucinski,Oliver James Pratt,Zulfikarali Premji,Michael Ramharter,Christophe Rogier,Lars Rombo,Philip Rosenthal,Patrick Sawa,Birgit Schramm,Carol Hopkins Sibley,Véronique Sinou,Sodiomon B. Sirima,Frank Smithuis,Sarah G. Staedke,Inge Sutanto,Ambrose O. Talisuna,Joel Tarning,Walter R. J. Taylor,Emmanuel A. Temu,Kamala Thriemer,Nhien Nguyen Thuy,Venkatachalam Udhayakumar,Johan Ursing,Michel Van Herp,Michèle van Vugt,Christopher J. M. Whitty,Yavo William,Cornelis Winnips,Issaka Zongo,Philippe J Guerin,Ric N. Price,Kasia Stepniewska

Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria : a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

2019

Prabin Dahal
Julie A. Simpson
Salim Abdulla
Jane Achan
Ishag Adam
Aarti Agarwal
Richard Allan
Anupkumar R. Anvikar
Emmanuel Arinaitwe
Elizabeth A. Ashley
Ghulam Rahim Awab
Quique Bassat
Anders Björkman
François Bompart
Steffen Borrmann
Teun Bousema
Ingrid van der Broek
Hasifa Bukirwa
Verena I. Carrara
Marco Corsi
Michel Cot
Umberto D'Alessandro
Timothy M. E. Davis
Marit de Wit
Philippe Deloron
Meghna Desai
Pedro Rafael Dimbu
Djibrine Djalle
Abdoulaye A. Djimde
Grant Dorsey
Ogobara K. Doumbo
Chris Drakeley
Stephan Duparc
Michael D. Edstein
Emmanuelle Espié
Abul Faiz
Catherine O. Falade
Caterina I. Fanello
Jean-François Faucher
Babacar Faye
Filomeno Fortes
Nahla B Gadalla
Oumar Gaye
J. Pedro Gil
Brian Greenwood
Anastasia Grivoyannis
Kamal Hamed
Tran Tinh Hien
David Hughes
Georgina S. Humphreys
Jimee Hwang
Maman Laminou Ibrahim
Bart Janssens
Vincent Jullien
Elizabeth Juma
Erasmus Kamugisha
Corine Karema
Harin Karunajeewa
Jean René Kiechel
Fred Kironde
Poul-Erik Kofoed
Peter G. Kremsner
Valerie Lameyre
Sue J. Lee
Kevin Marsh
Andreas Mårtensson
Mayfong Mayxay
H. Menan
Petra F. Mens
Theonest K. Mutabingwa
Jean Louis Ndiaye
Billy Ngasala
Harald Noedl
François Nosten
André Touré Offianan
Mary C. Oguike
Bernhards Ogutu
Piero Olliaro
Jean-Bosco Ouédraogo
Patrice Piola
Christopher V. Plowe
Mateusz M. Plucinski
Oliver James Pratt
Zulfikarali Premji
Michael Ramharter
Christophe Rogier
Lars Rombo
Philip Rosenthal
Patrick Sawa
Birgit Schramm
Carol Hopkins Sibley
Véronique Sinou
Sodiomon B. Sirima
Frank Smithuis
Sarah G. Staedke
Inge Sutanto
Ambrose O. Talisuna
Joel Tarning
Walter R. J. Taylor
Emmanuel A. Temu
Kamala Thriemer
Nhien Nguyen Thuy
Venkatachalam Udhayakumar
Johan Ursing
Michel Van Herp
Michèle van Vugt
Christopher J. M. Whitty
Yavo William
Cornelis Winnips
Issaka Zongo
Philippe J Guerin
Ric N. Price
Kasia Stepniewska

Background: Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potentially preclude/ ...

Keywords:

Drug
Meta-analysis
Individual participant data
Immunology
Malaria
Plasmodium falciparum
Intensive care medicine
Biology
competing risks
drug trial
Dihydroartemisinin/piperaquine
Parasitology

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