PREPARATION AND PROPERTIES OF A SMALL-PARTICLE AEROSOL OF COXSACKIE A21.

SummaryA method of generation and a description of the aerobiologic properties of small-particle aerosols containing the picorna-virus, Coxsackie A21, have been described. The size of particles in the aerosol ranged from 0.2 to 3.0 μ in diameter. Particles 1–2 μ in diameter comprised 54% of the total particle volume and contained 68% of recoverable virus. The SD among aerosol virus concentrations during periods of administration was 0.25 log10 TCID50. The log concentration of virus in the aerosol expressed as a function of the log concentration of virus in the suspension used to generate the aerosol was a straight line with a slope of 0.87. Virus concentration in the liquid suspensions tested ranged from 6.4 to 11.0 log10 TCID50/liter, and in aerosols from 0.3 to 4.3 log10 TCID50/liter. The mean difference in concentration between liquid and aerosol through the range of values tested was 106.3 log10 TCID50/liter.