Over-diagnosis of Rotavirus Infection in Infants Due to Detection of Vaccine Virus

Accurate rotavirus diagnosis is important for clinical management and monitoring active disease and vaccine effectiveness. Between 2016-2018, rotavirus-positive results in our laboratory were from vaccine virus shedding in 71/152 (46.7%) infants with a request for rotavirus testing. Routine diagnostic testing of infants should ideally distinguish vaccine from wild-type virus.