Pharmacokinetics of Lacosamide and Omeprazole Coadministration in Healthy Volunteers: Results from a Phase I, Randomized, Crossover Trial

Willi Cawello,Christa Mueller-Voessing,Andreas Fichtner

Pharmacokinetics of Lacosamide and Omeprazole Coadministration in Healthy Volunteers: Results from a Phase I, Randomized, Crossover Trial

2014

Willi Cawello
Christa Mueller-Voessing
Andreas Fichtner

Background The antiepileptic drug lacosamide has a low potential for drug–drug interactions, but is a substrate and moderate inhibitor of the cytochrome P450 (CYP) enzyme CYP2C19.

Keywords:

Lacosamide
Anesthesia
Cytochrome P450
Omeprazole
CYP2C19
Medicine
Crossover study
Pharmacokinetics
Diabetes mellitus
Pharmacology
Drug tolerance

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