Abstract 15137: Association of Congenital Heart Defects With Childhood Cancer in Privately Insured US Children: A Rapid Claims Analysis

Background: As treatment for congenital heart defects (CHDs) has improved, understanding the long-term outcomes of survivors has become important. Recent studies have focused on the risk of adult-onset cancer in CHD survivors, but little is known about the incidence of childhood cancer in this population. Our objective was to determine the association of CHDs with childhood cancer using a nationwide administrative healthcare database of more than 100 million Americans. Methods: Using the Treatment Pathways online analytic interface to access the Truven Health MarketScan® research databases, we examined the presence of ICD-9 diagnosis codes for neoplasm during 2009-2015 among 6.1 million children <18 years of age not coded for Down syndrome, continuously enrolled in employer-sponsored plans during 2014. To avoid overestimating the risk of cancer in CHD survivors, only those children with ≥1 CHD code during 2009-2014 ≥30 days prior to the first neoplasm code were considered to be CHD survivors with cancer. ...