Pharmacokinetics and Tolerability of the Orally Active Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 in Healthy Volunteers

Helen Swaisland,Alison Laight,Lesley Stafford,Helen Jones,Charles Morris,Aaron Dane,Roger Yates

Pharmacokinetics and Tolerability of the Orally Active Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 in Healthy Volunteers

2001

Helen Swaisland
Alison Laight
Lesley Stafford
Helen Jones
Charles Morris
Aaron Dane
Roger Yates

Objective: To investigate the pharmacokinetics and tolerability of ZD1839 (Iressa™), an orally active selective epidermal growth factor receptor-tyrosine kinase inhibitor, in healthy volunteers.

Keywords:

Epidermal growth factor
Tyrosine
Epidermal growth factor receptor
Kinase
Pharmacology
Tyrosine-kinase inhibitor
Enzyme inhibitor
Pharmacokinetics
Tolerability
Biology
Medicine
Endocrinology
Oral administration
Internal medicine

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