Genetic remodeling of gangliosides resulted in the enhanced reactions to the foreign substances in skin

Department of Pediatnc Dentistry and 'Department of Prosthodontology I, Nagasaki University School of Dentistry,' Department of Histology and Cell Biology, Department of Oncology, Department of Pediatrics, Nagasaki University School of Medicine, Sakamoto, Nagasaki, 852, Japan, 'Department of Biochemistry and 'Department of Internal Medicine II, Mie University School of Medicine, Tsu, Mie, 514, Japan, and 'Department of Genetics, Genetic Research Institute, Kumamoto University School of Medicine, Kumamoto 860, Japan To whom correspondence should be addressed 'Present address: Nagoya University School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, 466, Japan